Diabetes and Diabetes Complications

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Diabetes and Diabetes Complications

Postby Chensm » Wed Nov 08, 2006 10:34 am

Diabetes is called "the Mother of all Diseases".The World Health Organization (WHO) estimated that there were 250 million diabetics living around the world; resulted diabetes ranks fifth among the ten major causes of death in the world. 4 people died cause by diabetes or it complications every minutes. It is estimated that diabetics account for 6%~15% of the population in all countries. And the number of diabetics is increasing most rapidly in Asia. Cost of diabetes treatment was close to USD100 billion every year.

Asia have the highest number of diabetics patients
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In 21 century, especially in 2025, diabetic Mellitus will be a formidable enemy to the health of mankind. As diabetes is the root cause of all kinds of diseases and ailments.

The World Health Organization (WHO) estimated that there were 189 million diabetics living around the world in2003. This figure is expected to sharply increase to 324 million in 2025. In other words, diabetes will increased about 72% in the next 22 years.

Asia has the highest amount of diabetes patients around the world. Increase 91% from 81.8 million in 2003 to 156.1 million in 2005.

Mejar Jeneral Dato' (Dr) Sulaiman bin Abdullah who is Director General of Health Services Malaysian Armed Forces,Health Services Division,Headquaters MAF, Ministry of Defence mentioned diabetes complications in recent interview:

Heart disease
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Including Atherosclerosis and Myocardial Infarction: The risk of dying of heart disease is 2 to 4 times higher in diabetic adults compare to non-diabetic adults.

Stroke
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The risk of stroke is 2 to 4 times higher in diabetic patients than in normal persons.

High Blood Pressure
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It is estimeted that approximately 60 to 65% of diabetics patients have High Blood Pressure.

Kidney Failure
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20 to 40% of diabetes patients have kidney disease or kidney failure or renal dialysis. Diabetes is the main cause of kidney failure.

Blindness
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A leading cause of blindness among adult age between 20 to 70 is diabetic retinophathy and glaucoma.

Nerve damage
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60 to 70% of diabetes patients may have certain degree of damage in circulatory and nervous system.

What is diabetes
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Diabetes is a chronic disease. When the pancreas in the body is unable to secrete sufficient insulin or unable to untilize insulin effectively, leading to high sugar levels, diabetes will develop.

Hyperglycaemia and other metabolism illness may cause damage to a lot of human organ especially nerves and vascular system.

Type 1 Diabetes
--------------------

Diabetes is generally divided into types I and II.

Type1 Diabetes : Usually caused by abnormal insulin production by the pancreas. Cause by human immune system killing each other cells. Approximately 10% of diabetes patients is Type 1, usually children and youths.

Type 2 Diabetes : Patients are still able to secrete insulin, but cannot effectively use insulin. The main cause of Type 2 diabetes is the reduction of insulin and insulin receptor sensitivity causing cells cannot utilize blood glucose efficiently call Insulin Resistance. Type II diabetes accounts for 90% or more of all patients, usually adult.

Diabetics Data
------------------

WHO once sets a standard to diagnose diabetes:

Patients have an empty-stomach blood sugar concentration 7.8 mmol/L may be diagnosed diabetics

Patients have a blood sugar concentration = 11.1 mmol/L at any time (including any time after meals) may be diagnosed diabetics.

If a patient's blood sugar concentration is intermediate between the two figures given above, the Oral Glucose Tolerance Test (OGTT) should be given to determine whether the patient's condition is due solely to poor glucose tolerance. If empty-stomach blood sugar is 7.8 mmol/L and blood sugar concentration is between 7.8 mmol/L and 11.1 mmol/L within two hours of taking glucose, the patient should be diagnosed as having impaired glucose tolerance (IGT). These patients may later develop diabetes if prompt preventive measures are not taken.


Cause of Type 2 diabetes
--------------------------------

Type 1 diabetes usually caused by damage to the pancreas genes and abnormal of immune system. Type 2 diabetes usually cause by the following:

1) Prolong dependent on drug or injection: e.g.: Steroids

2) Diabetes during pregnancy.

3) Illness related to pancreas including pancreatectomy, pacreatic cancer, pancreatitis, haemochromatosis.

4) Excessive sugar intake

5) Edocrine disorder: edema of the face, acromegaly and neuroma of the urinary bladder.

Symptoms of diabetes
-------------------------

Some patients, by chance, during one of their blood tests, are shocked to learn that they are diabetics. Nevertheless, by paying more attention, if a person suffers from diabetes, the following symptoms will show:

1) Drop in body weight

2) Fatique, even feeling sleepy

3) Weak and easy infected by virus and bacteria

4) Excessive urine (polyuria) and thirst (polydipsia) : This is because blood sugar affects the function of the kidney that filters fluids.

5) Ketoacidosis commonly occurs in Type I diabetes patients. Low insulin may cause dehydration, exhaustion, fever, low blood pressure, short of breath, possibility of shock or even death.

Kidney Failure
----------------

Diabetes cause disorder of kidney including diabetic nephritis. A person urine have 30-300mg of Micro-Albuminuria every 24 hours. If A person have more than 10 to 15 years of diabetes history and his urine have more than 300mg of Micro-Albuminuria. He has kidney failure and require dialysis.

This may lead to diabetic retinophathy and glaucoma and cause blindness.

Nerve damage
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Diabetes will seriously damage the nervous system of the patients. The damage to the nervous system can be divided into the following sections:

1) Nerve damage occur in feet , the sufferer may complain of numbness.

2) Neuritis: usually occurs on 3 nerves, which are the nerve in the skull, nerve of the arms and nerve of lower limbs, all of which will feel pain.

3) Amyotrophy

4) Autonomic Neuropathies. autonomic nervous system is the nerve system that "make it own decision" and is not affcted by willpower. autonomic neuropathaties will cause hypoglycemia (low blood pressure) like dizziness, impotence, nocturnal diarrhea and retention of urine.

Diabetic foot sores
----------------------

Diabetes may cause serious complications like gangrene (or diabetic feet).

When ulcers appear on the legs of diabetic patients, bacteria will invade the soft tissues and bones of the legs. In this way, the joints of the legs become distorted. During the early stage, the nerve can still feel pain but during the late stage, the legs become numb and are easily injured, for example, when stepping a stone or protruding matter, the legs do not have any feeling even if the legs bleed. When angiopathy develops in the legs, the blood vessels become narrow or are blocked. The toes are the first affected.

When the toes bleed, the toes will ulcerated area increases, the patient are forced to have their legs amputated.

Under such circumtances, the biggest sorrow of human life is cause by diabetes.

Published by Sin Chew Daily dated 20 March 2006 (Part 1)
Excerpt and translated by http://www.DiabetesMilkPowder.com
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Postby nightwing » Wed Nov 08, 2006 11:06 am

Thanks for sharing. Good to have this infomation.
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Postby Chensm » Thu Nov 09, 2006 7:14 am

Welcome
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Drugs for diabetes and it side effects

Postby Chensm » Thu Nov 09, 2006 7:21 am

Drugs for diabetes and it side effects
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There is no drugs to cure diabetes at the moment. The main medical treatment is to control it and lower blood sugar level; It is not easy to achieved this unless the patient : 1) Understand the important of control blood sugar level. 2) He must have strong willpower to control the desire for food and prevent excessive eating and drinking 3) Frequently consult the diabetic specialist, eye specialist, diet therapist and foot therapist, sothat the patient understands his/her condition clearly, that is, whether his/her condition is under controlled.


The goal is to control the patient’s blood sugar level
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Director General of Health Services Malaysian Armed Forces in Health Services Division of Headquaters MAF, Ministry of Defence, Mejar Jeneral Dato' (Dr) Sulaiman bin Abdullah in a recent interview stated that the Diabetic Controland Research Center in UK discover that if diabetes patients able to control his blood glucose level. Then, he able to reduce the risk of "capillaries complication"

Reduce major and minor angiopathy
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The centre also find that if diabetic able to control his blood pressure ( less than 130/70mmHg) level, he can reduced the risk of "major capillaries and minor capillaries".

The centre stress that diabetic patients must pay close attention to their vision and check whether they are suffering from rethinopathy.

Maj Gen Dato (Dr) Sulaiman Bin Abdullah also mentioned that the Diabetics foot is another important issue. They should consult foot specilists frequently to check the condition of their foot on:


Prickling pain
Ulcers or dead muscle
Neuropathy of the legs


Diet Control
------------------

One method to control diabetes and lower blood glucose levels is diet control:

1) Reduce intake of high calories food to reduce the accumulation of fats in the body and maintain ideal weight.

2) Reduce intake of fatty food to delay the development of Atherosclerosis .

3) Reduce intake of sugary food to prevent increase in blood glucose level

4) Increase intake of vegetables, especially high-fiber vegetables, to help to reduce blood sugar levels. In the meantime, this also prevents the sudden decrease in blood sugar because the sudden decrease in blood sugar will result in Hypoglycaemia.

Blood Glucose reducing drugs
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There are a few type of drugs that reduce blood sugar levels and the most important drugs are the Sulphonylureas family and Biguanides family.

Sulphonylureas
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The machanism of this type of drugs is replenishing insulin secretion. In other words, the alpha cells of the pancreas in the patients body are still able to secrete low but in adequate amount of insulin. Therefore, this type of drugs augments the secretion of insulin from the pancreas. There are several brand names for this family of drugs but their therapeutic effects are very much the same.

Side effects :

There is a risk of low blood pressure especially in elderly patients who has taking this drug for a long period of time. Therefore, this type of drugs must be prescribed by medical specialists.

This type of drugs encourage weight gain. The condition is worse in obese patients as obesity will increase the insulin resistance in the body. This is because the cells are covered by a layer of fat oil. Thus, it is more difficult for pancreas to open the "door" (receptors) of the cells to allow the blood sugar to enter.

Biguanides
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Currently there is only one brand name for this family of drugs, which isl "Metformin". The mode of action of this drug is reducing the source of blood sugar, which is also assisting insulin to allow more blood sgar to enter into the cells. At the same time, this drug can also strengthen the tissues in the human body sothat more blood sugar can be utilized. This type of drug has the following benefits:

1) Suitable for type 2 diabetic patient

2) Suitable for obese diabetic patient. This drug is the first line medicine used by obese diabetic patients.(Translator note:Anorexic—Because of this function, Biguanides suitable for obese patients to cause them to reduce their food intake, lower their body weight, and improve the peripheral function of insulin.)

Side effects:

The side effect of this type of drug is the discomfort in the stomach and intestines. Hence, this drug should be taken after meal. However, those with kidney disorder should not take this type of drugs.

Thiazolidinediones
----------------------

This type of drugs is able to enhance sensitivity of insulin. In other words, it helps blood sugar to enter into cells more easily. If Sulphonylureas and Biguanides mentioned above fail to reduce blood glucose level effectively, then thiazolidinediones drugs should be used.

Acarbose
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Blood glucose levels definitely increase after the patients has eaten meal. This type of drugs is able to reduce the blood glucose levels increased after a meal.

Side effect: The side effect is sometimes the drug might cause flatulence

Insulin
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Nearly 25% of diabtic patients need to inject insulin. It is a type of Polypeptide Hormone. When insulin comes into contact with gastric acid, it become ineffective. Therefore, the patients have to inject into body directly.

After Insulin injection, the patients should monitortheir blood glucose levels. The blood glucose level after meal should between 4 to 9 mm01/L. Most patients should use insulin of mid-term effects and with two injections per day.

The drugs mentioned above are different methods to reduce the blood glucose in diabetic patients. Although they have high therapeupic effects, each type of drugs does have their side effects.

Glossary
======

Doule bind
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Double-blind test ia a special experimental condition where both the principal investigators (or doctors) and participants (or patient) do not know the nature, procedure and whether the treatment given contains the real medicine, or is merely made up of placebo's hence both are blind, so that any placebo effects and cues during the process of the experiment are eliminated or prevented.

Glucose Tolerence Factor and Diabetes
---------------------------------------------

Glucose Tolerance Factor (GTF) is found in our body tissues and cells. Its main function is to maintain normal glucose metabolism in the body. Glucose Tolerance Factor (GTF) also known as “insulin booster.” Insulin must interact with GTF and insulin receptor to successfully send glucose into cells so it can be converted to energy. GTF is a compound consist of trivalent chromium plus minerals, vitamin, and amino acids.

Long term insufficient trivalent chromium intake will result in the decrease of GTF synthesis in our body, and glucose will not be transported into the cells efficiently. Thus, insulin resistance and clinical symptoms of diabetes develop. The presence of excess glucose in the urine will use up more glucose tolerance factor. This lead to serious trivalent chromium deficiency and the gradual loss of kidney functions. This is also one of the main reasons diabetic patients suffer from kidney disorder.

Insufficinet trivalent chromium may cause insulin resistance, affecting glucose and lipid metabolism. Other than diabetes, it will also cause clinical symptoms such as abnormal blood lipid levels and cardiovascular diseases.

GT&F Milk Powder
---------------------

On 15 January 2006. Malaysia visiting group made a trip to Taiwan to learn about the development of a milk powder that was manufactured diabetic patients - GT&F Milk Powder which contains Glucose Tolerence Factor ( GTF ).

Dr. Kuo Shi-Wen,Director of Division of Metabolism and Endocrinology at Buddhist Xindian Tzu Chi General Hospital, Taiwan has. as a team leader, conducted a Double-blind test on GT&F milk powder. The result is very encouraging. 156 male and female Type 2 diabetes paticipant in the test. After taking GT&F milk powder for 4 months. Majority of the patient's "Insulin Resistance" symptom has been lower. The clinical test has shown that GT&F® Milk Powder is effective in lowering fasting plasma glucose in diabetes patients.

The Clinical Test Results has received compliment from The 25th Annual Meeting of The Endocrinology Society and The Diabetes Association of The R.O.C. 2004.

Beside that, the results were also recognised and published by International Journal of Clinical Practice.

Taiwan National Chung Hsing University Trial
----------------------------------------------------

President of Taiwan National Chung Hsing University, Dr. Jei-Fu Shaw(pic), who has a Ph.D. (Biochemistry) from University of Arkansas (1977), and is also a Fellow Member of American Association for the Advancement of Science(AAAS).

The university conducted an experiment on mouse by using GT&F Milk Powder. After 4 months, they also discover that GT&F Milk Powder is able to control diabetes from deterioration reduce blood glucose level without any side effect.

Published by Sin Chew Daily dated 21 March 2006 (Part 2)
Excerpt and translated by http://www.DiabetesMilkPowder.com
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GT&F Milk Powder able to lower diabetics' blood glucose

Postby Chensm » Thu Dec 14, 2006 8:06 am

GT&F Milk Powder able to lower diabetics' blood glucose level
========================================

Two "Double blind" clinical test were conducted in Taiwan and proved that " GT&F milk powder " able to lower diabetics' blood glucose level without any side effect.

Double blind test in Tzu Chi General Hospital,Taiwan


There is a revolutionary breakthrough on diabetes healing and control by Taiwan medical specialist recently.

The achievement is some diabetes patient able to lower and control their blood glucose level effectively by taking " GT&F Milk Powder ".

This accomplishment is acheived through a "double blind" test. The head of the team that conducted the experiment is Dr. Kuo Shi-Wen.

The venue of the clinical trial is at Buddhist Xindian Tzu Chi General Hospital, Taiwan.

The author of this article (Translator Note: The author of this article is a journalist with Sin Chew Daily in Malaysia) went to Tzu Chi General Hospital under a special arrangement to conduct an exclusive interview with Dr Kuo Shi-Wen. Who is Director of Division of Metabolism and Endocrinology with Buddhist Xindian Tzu Chi General Hospital, Taiwan.

He reveal that : We have done a randomized and double blind test in Tzu Chi General Hospital, Taiwan. The objective of the trial is to review the reaction and safety of diabetes patients after taking " GT&F Milk Powder ".

Another important reason for this project is: Insulin produced by pancreas of type 2 diabetes patients usually low quality and insensitive. In order to open the receptors of cells for the blood sugar to enter into the cells, this insulinhas to depend on the help from Glucose tolerance Factor ( GTF ) especially the Trivalent Chromium, an element in Glucose tolerance Factor (GTF) .


There is usually a "trivalent chromium" deficiency in the blood of type 2 diabetic patients. This is the reason the conditions of diabetics deteriorate.
Taiwan's medical specialist has successfully extract trivalent chromium and add it to milk powder to become " GT&F Milk Powder "
The target of our experiment is this GT&F MilkPowder. Can the milkpowder really reduce and control the blood sugar levels in diabetic patients after consumption? If yes, at what level is the milk powder able to control the blood sugar?


Able to Control animal blood glucose level

Animal test, e.g. : rat indicated that its has improved its glucose and lipid metabolism after taking milk powder with trivalent chromium.

Elderly have less Trivalent Chromium

Other research show that when a type 2 patient aged, and become elderly, trivalent chromium within their body would reduced with age.

Trivalent Chromium able to control increase in blood glucose level


In 1997, a research conducted by Dr Anderson indicated that after a type to diabetes patient taking milk powder with rich trivalent chromium (500-1000mcg). The patient successfully control their blood glucose level and prohibit their blood glucose level to increase.

*According to US standard : 200mcg of trivalent chromium in milk powder daily is sufficient.

*Glucose tolerance Factor Milk Powder ( GAD&F Milk Powder ) do not have side effect and is non-toxic.

*As it has been proven that such milk powder able to lower animal glucose level. Thus, we now conducted a clinical test on type 2 diabetes patients.


156 Diabetes Patients

The detail of the clinical trial are as follow:

We have recruited participant from type two diabetes patients: Male or female, age between 30 to 75.

Currently, they are consuming oral medicine for diabetes for the pass 2 months and their blood glucose level has been stablelise.

We have successfully recruited 156 patients to participate in this trial.

Patients' FPG between 140-250mg/d1 and HbA1c level between 7.5-12%.

Patients' empty-stomach triglyceride level were less than 400mg/d1. Body Mass Indexes (BMI) were between 20-35kg/m2.

Only patients who gave informed consent were recruit as study participant.

Duration of treatment: 16 weeks ( 4 months ) . Double blind test : Group A and Group B.

Evalution of therapeutic effects : On the 16th weeks, group A patients' HbA1c level has changed. On the 16th weeks, all group A's patients' FPG;insulin rejection(HOMA); Cell B; Total Cholesterol, HDL-Cholesterol, LDL-Cholesterol and triglyceride level has changed.

GT&F Milk powder is one of the nutrition supplement for diabetic patients. It has proven to be save and have therapeutic effects

Recognition from international journal

HOMA levels from Group A and Group B female patient has substantially reduced after 16 weeks of taking the milk powder, further research required to be done to find out the reason of such improvement.

We have produced a report on such clinical trial and presented it on Annual Meeting of The Endocrinology Society and The Diabetes Association of The R.O.C. in 2004(EASD), and has been accepted and published by an international clinical trial journal. We feel honor on this.

Second Trial

Other than the above, we have conducted another double blind test. Some of the distinguished features of the experiment are shown as follow:

Number of paticipants : 40. Ratio between male and female is 20:20. All are type 2 diabetes patients.

Patients were divided into Group A and Group B: Group A patients consumed GT&F Milk Powder whereas Group B patients consumed Placebo milk powder.

Duration: 16 Weeks

Venue : Tri-Service General Hospital

Below are our second trial:

[table] [mrow] Participants'Details [mcol] GT&F Milk Powder [mcol] Placebo
[row] [col] ( 20 persons ) [col] ( 20 persons )
[row] Age [col] 54.2+-7.1 [col] 55.6+-8.2
[row] Sex (Male/Female) [col] 10/10 [col] 10/10
[row] BMI (Kg/Mz) [col] 25.2+-4.1 [col] 26.2+-3.2
[row] Diabetes aged (Months) [col] 58.1+-16.1 [col] 60.1+-15.2
[row]Empty-stomach blood glucose level (mmol/L) [col] 9.72+-2.3 [col] 9.53+-3.1
[row]Empty-stomach blood insulin (pmol/L) [col] 62.5+-31.2 [col] 56.7+-28.5
[row] HbA1c [col] 9.3+-0.9 [col] 9.1+-1.1
[row]Insulin Resistance ( HOMA-IR ) [col] 4.42+-1.82 [col] 4.17+-2.01
[row] Insulin Sensitivity (SI,10-5min-1/pm ) [col] 0.21+-0.67 [col] 0.25+-0.52
[row] (EG, MIN-1) [col] 0.138+-0.49 [col] 0.126+-0.32
[row](AIR, PM) [col] 222+-146.2 [col] 246+-126.8 [/table]

Conclusion:

*Milk Powder with Trivalent Chromium has therapeutic effects, safe and without side effect on type 2 diabetic patients.

*For male patients: Such Milk Powder able to lower FPG, FPI and HOMA levels. This is a conclusion after a comparison with diabetic patients consuming placebo milk powder.

*Such trial has been compile in report and presented at the Annual Meeting of The Endocrinology Society and The Diabetes Association of The R.O.C. 2005(EASD meeting), and has been accepted and published by Metabolism Journal.http://www.journals.elsevierhealth.com/periodicals/ymeta/article/PIIS0026049506000837/abstract

Translated from Sin Chew Daily dated 23 March 2006 (Part 4)
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A New Explanation For Diabetes

Postby Chensm » Tue Feb 06, 2007 3:25 pm

[b]A New Explanation For Diabetes
=====================

Diabetes is a chronic disease, with the mechanism for the cause of the disease unknown, and cannot be cured permanently. Despite controlling their conditions by diet, exercise and drugs for years and years, the conditions of some diabetics patients still deteriorate. Therefore, those in the medical field have been trying very hard to search for a cure to treat diabetic patients. Although cannot cure diabetes permanently, "GT&F Milk Powder", a health care product recently researched and developed in Taiwan, provides an alternative for patients and the high risk group.[/b]

There is no efficacious medicine to deal with diabetes. It only depends on the patients' own diet control and regular exercise. If all of these fail, external help by using drugs is required.

Currently, there are five types of drugs that are used to control the blood sugar levels in the patients. The first kind of drug inhibits the production of glucose in the liver and the second type acts by stimulating the secretion of insulin. The third type of drugs reduces the resistance against insulin in the body while the fourth type improves the rapid secretion and losses of insulin when the disease attacks the patients. The fifth type of drug inhibits the break down of carbohydrates in small intestines, so that sugar absorption is reduced.

Although more and more drugs are being researched and develop in recent years, they seemed to be merely alleviating the symptoms rather than curing the disease completely. After consuming drugs, some Type 2 diabetic patients do experience gradual loss of control over their conditions. Thus to improve the effects, treatment by insulin injection is required.

Open Up A New Path

Type 2 diabetes, which accounts for most of diabetic cases, is not caused by insulin deficiency. It is only the decrease in the sensitivity of insulin receptor that makes the cells unable to metabolize glucose. Despite increasing the insulin dosage, the effect is still limited.

Specialists pointed out that high level of glucose in the blood is only a symptom. The crucial factor is " the glucose unable to enter into the cell". Hence, "the permanent cure should be aiding the absorption of glucose".

How to strengthen the bioactivity of insulin and the sensitivity of receptors is a new research direction for diabetic treatment. Research on "Glucose Tolerance Factor" is one of them.

Glucose tolerance factor is present in tissues and cells. The main functions are to maintain the metabolism of glucose in the body, work together with insulin to transport glucose from blood into cells in the body.

As early as in 1957, American biologist Dr. Walter Mertz and Dr. Klaus Schwarz had discovered Glucose Tolerance Factor in mamalian kidney. Later on, it was proven that this compound, which consists of vitamin, amino acid and trivalent chromium, is the essential molecule to activate the insulin receptor. It able to reduce blood glucose level effect, of which, trivalent chromium is the key element.


Trace amount of chromium elements is present in the human body. Chromium is mostly accumulated in the bone marrow but chromium levels reduce with the increase in age. The loss of chromium is more serious under obesity, pregnancy, alcoholism, over work and over stress conditions.

It is not easy to replenish chromium. Chromium is present in the colostrums milk, liver and kidney of animals and in cauliflower, potato, grapes and orange in the food. however, chromium from those sources are not easily absorbed by human body because they are ingested, they combine easily with the fibers in the gastrointestinal tract and are excreted out of body together with faeces.


Prevention and treatment

Position as a health care product, the objective of "GT&F Milk Powder" is to regulate physical functions and enhance metabolism. The target is not limited to diabetic patients only.

Besides diabetic patients, special care should be given to obesity and hereditary high risk group. Specialists pointed out that conditions of the body cannot be clearly cut off by a single line drawn by human. So, before crossing the line, we should take good care of ourselves.

"Prevention is better than cure". this is especially true in dealing with the epidemic disease of the 21st century.........diabetes.

Published by Sin Chew Daily dated 23 March 2006
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Re: Diabetes and Diabetes Complications

Postby remedyforhealth » Fri Feb 13, 2009 10:40 am

Good News for Diabetic people.
Pls visit our blog for more information.

http://remedyforhealth.blogspot.com/
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